Anti-Aging
Aging skin doesn't ask for one thing! It asks for several. And rarely all at once.
That's why our anti-aging range runs as separate lines rather than one cream claiming to do everything. Active Age works on firmness and slackening with peptides and multimolecular hyaluronic acid. Chrono Age® is for skin under stress (tired, dull, taking a beating from weather and pollution). Skin Perfection targets dullness and uneven tone.
Everything here is made in Italy and built on a physiological approach, which means working with the skin's own processes rather than against them. Not sure where to start? There's a guide below the products, or begin with the Skin Perfection Kit.
How to choose an anti-aging line for your skin
Most people arrive here knowing they want "something for aging". Nothing more specific than that. Fair enough! Here's how the range divides up, so you can skip the parts that aren't for you.
Start with what's bothering you, not with your age
Your birthday is a poor guide to what your skin needs. The mirror is a better one.
If the issue is firmness (skin slackening, features softening, a jawline that isn't holding the way it used to) then you want Active Age. The whole line is built around the PeptiHyal-System™, which pairs antiage peptides with multimolecular hyaluronic acid. Tripeptide-38 counteracts skin slackening by promoting the synthesis of collagen and elastin fibres. Niacinamide and panthenol reconstitute the natural epidermal barrier. There are eight products in the line: Instant Lift Ampoules, four creams and three serums, so you can start small. The Active Age Filler Cream is the usual first step.
If the issue is stress (skin that looks tired and grey, that's been through a hard winter or a harder year, that reacts to weather and pollution) then you want Chrono Age®. It's built on ATiPenergy, which revitalizes skin energy. Isoquercetin and papaya extract bring antioxidant action. Escin and red grape leaf extract promote circulation and strengthen blood vessels, so results here tend to show up as brightness rather than tightness. Chamomile, mallow and calendula keep the whole thing calm. The Chrono Age® Repair Face Cream is where most people begin.
If the issue is dullness and uneven tone, meaning not lines so much as a complexion that's lost its light, then you want Skin Perfection. The Boost range within it suits all skin types.
The three lines at a glance
| Line | Best for | Built around | What you'll notice |
|---|---|---|---|
| Active Age | Firmness, slackening, softening features | PeptiHyal-System™: Tripeptide-38 + multimolecular hyaluronic acid | Helps improve the look of firmness and the appearance of fine lines |
| Chrono Age® | Stressed, tired, dull skin; pollution and weather | ATiPenergy, isoquercetin, papaya, alpha lipoic acid, escin | Visibly renewed, brighter-looking skin |
| Skin Perfection | Dullness and uneven tone, all skin types | The Boost range: retinol, collagen, hyaluronic acid, vitamin C | Helps improve the look of tone and clarity |
What "Italian dermocosmetic" actually means here
The phrase isn't a marketing flourish. Dermophisiologique has spent forty years on dermatological and scientific research, and every formula follows a physiological approach: tolerable products that respect the nature of the skin rather than overwhelming it.
That exclusion list dates back to the year 2000, two decades before most brands got round to it! And in 2015 Dermophisiologique became the first professional cosmetic company in the world to gain B-Corp certification for environmental sustainability and social responsibility, which means there's no plastic in the packaging and the paper is recycled.
Building a routine that holds together
You don't need everything at once, and honestly we'd rather you didn't buy it that way. Pick the line that matches your main concern, use it consistently for a full season, then add to it once you know how your skin responds. Orders over $125 ship free, so a pair of products often works out better than one.
If you'd like to read further before choosing, our guides to collagen and retinol cover the science behind most of what's on this page.
One thing matters from day one, whichever line you choose. Wear sunscreen. Every day. UV is the largest single contributor to how skin ages, and an anti-aging routine without daily SPF is like a bucket with a hole in it! My Sun SPF 50+ Protective Cream layers over your serums without arguing with them, because there is no white cast to sit on top.
Anti-aging skincare FAQs
What age should you start using anti-aging skincare?
There's no single right age. It depends on your skin rather than your birthday. Prevention is easier than correction, so daily sunscreen and an antioxidant are worth starting early. Peptide-based firming products like the Active Age line tend to make most sense once you notice slackening rather than before.
What's the difference between Active Age and Chrono Age?
Active Age and Chrono Age® solve different problems. Active Age is a pro-aging line built on the PeptiHyal-System™ (peptides plus multimolecular hyaluronic acid), and it targets firmness and slackening. Chrono Age® is for stressed skin: tired, dull, worn down by weather and pollution. It uses ATiPenergy and antioxidant flavonoids to rebalance the skin's natural functions.
Do peptides actually do anything for aging skin?
Peptides are signalling molecules. In the Active Age line, Tripeptide-38 counteracts skin slackening by promoting the synthesis of collagen and elastin fibres. Those fibres are what give skin its structure. Results build gradually. Nothing here works overnight.
Can you use anti-aging products if your skin reacts easily?
Often, yes. It pays to introduce one product at a time, though. Dermatological testing applies across the whole range, and the formulas leave out alcohol, mineral oils, petroleum derivatives, synthetic dyes and added parabens. If your skin reacts easily, the Sensiderm line is formulated for delicate skin and pairs well with actives from elsewhere in the range.
When should you expect anti-aging skincare to show results?
Skin renews on its own schedule. Give any new routine a full season before judging it. Hydration and texture usually shift first. Changes in firmness and the look of fine lines take longer, because they depend on processes happening deeper down.
Where should a complete beginner start?
Pick one line. Pick one product. If firmness is the concern, start with the Active Age Filler Cream. If tiredness and dullness are the issue, the Chrono Age® Repair Face Cream is the one to reach for. Add sunscreen either way.
Is Dermophisiologique cruelty-free and sustainable?
Dermophisiologique was the first professional cosmetic company in the world to gain B-Corp certification, back in 2015, for environmental sustainability and social responsibility. The packaging contains no plastic, the paper is made from recycled material, and the colors used are water-based.